Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student's perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Guide ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin is the significant component of the newest red color regarding turmeric, an enthusiastic Indian liven that's taken from the brand new rhizome of your own exotic plant Curcuma longa, and that belongs to the Zingiberaceae nearest and dearest. Within section, i discuss the pharmacological circumstances regarding curcumin and you may explore the molecular angles for those things. I up coming review new proven and you may prospective health-related uses regarding curcumin. Curcumin is well known over the years since the a healing agent, but its apparatus away from step is actually in depth. The new pharmacological results of curcumin seem to be the consequence of an excellent synergism off sites away from poor biochemical affairs having multiple physiological plans from inside the interrelated signaling pathways. These types of goals include minerals such as for example cyclooxygenase, lipoxygenase and you may protein kinases, and you may transcription items instance NF-?B, STAT and Nrf2. Modulation ones particles affects downstream affectors which make this new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you may antimicrobial facts regarding curcumin. These consequences was tested during the medical products from curcumin for soreness and you will inflammatory disease, cancers, Alzheimer state, aerobic infection, and you will diabetic issues. The brand new products have tried variable doses out-of curcuminwith various other wavelengths and you can course, into general conclusion that higher amounts from curcumin during the number of g have to see therapeutic outcomes. Read more
Publication Section Samples of plant-derived pharmaceuticals that have become the focus out of proceeded and you can great research and innovation focus keeps, to date, been a little scarce. Д°talyanca sД±cak kД±zlar Once a long period, the last two decades was in fact described as an effective 100-bend escalation in what amount of scientific blogs had written per year you to was off relevance to the accessibility curcumin inside the biomedicine. Read more
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many prospective pharmacological consequences that can features healing applications in a lot of condition says, because talked about in detail in the previous section. Yet not, the potential scientific effectiveness from curcumin is bound because of the their physicochemical features out of poor drinking water solubility and you will imbalance, and therefore bring about lower bioavailability. Prodrugs off curcumin give an approach to improvement of the biopharmaceutical and you may pharmacokinetic services, and may even ensure it is exploitation of your own pharmacological negative effects of curcumin. Contained in this section, i earliest remark the new physicochemical and pharmacokinetics out of curcumin. I up coming determine the appearance of curcumin prodrugs with increased h2o solubility and enhanced agents balances and this can be translated to free curcumin up on bioactivation for the vivo. I emphasize recent achievement of this type, that have a concentrate on the structure, synthesis and you may assessment of prodrugs centered on promoieties and additionally amino acids, essential fatty acids, nucleic acids, dicarboxylic acids, and you will polymeric product including hyaluronic acid and you will polyethylene glycol. It section comes with the reason for optimization of one's physicochemical and you can biopharmaceutical attributes and also the physiological products of curcumin prodrugs, on the mission playing with of those curcumin types during the systematic applications. Find out more
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